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Prednisone and indomethacin. Prednisolone, indomethacin similarly effective for acute gout |
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❿Oral Prednisolone, Indomethacin Equivalent in Relieving Acute Gout Pain - Full Image
Oral prednisolone is as effective as indomethacin for relieving pain in acute gout and should be considered a first-line treatment option, according to a report published online Feb. Colchicine and nonsteroidal anti-inflammatory drugs have been considered the first-line treatment for acute gout for many years. Timothy Hudson Rainer of the emergency medicine academic unit, Cardiff Wales University, and his associates.
They performed a double-blind, randomized trial comparing oral indomethacin against oral prednisolone in patients who presented during a 2-year period to the emergency departments of four Hong Kong hospitals, where acute gout typically is treated in the ED. Those who were randomized to indomethacin initially received 50 mg two mg tablets of the drug three times a day and six tablets of oral placebo prednisolone once a day for 2 days, followed by 25 mg of indomethacin three times a day and six tablets of placebo prednisolone once a day for 3 days.
Prednisolone-treated patients initially received 30 mg three mg tablets of the drug once a day and two tablets of placebo indomethacin three times a day for 2 days, followed by 30 mg three mg tablets of prednisolone once a day and one tablet of placebo indomethacin three times a day for 3 days. All the patients received 1 g oral paracetamol to be taken every 6 hours as needed. Treats inflammation problems, such as rheumatoid arthritis, osteoarthritis, and acute gout attacks.
In studies, Indocin indomethacin was more effective than Tylenol for treating osteoarthritis pain. It works as well as Celebrex for treating an acute gout attacks. Available in capsules, long-acting capsules, suppositories, and as a suspension. All forms, except the suspension, are available as generic medications. Deltasone prednisone effectively treats a variety of conditions involving the immune system.
Can help improve energy and stimulate your appetite. Works quickly to provide relief for swelling, rash, asthma attacks, and pain. Good long-term treatment option for autoimmune disorders. Deltasone prednisone is available in a generic form. Indocin indomethacin can cause serious heart and stomach problems. Published: Jul 13, Last Updated: Oct 27, Taking Indomethacin With Prednisone In our latest question and answer, the pharmacist discusses whether or not it is safe to take indomethacin with prednisone.
Answered By: Dr. Brian Staiger Pharm. Jul 12, Was this article helpful? We'll never share your email with anyone else. Submit Close. Related Questions.
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In our latest question and answer, the pharmacist discusses whether or not it is safe to take indomethacin with prednisone. Yes, there is a potential interaction between prednisone, a corticosteroid, and indomethacin. However, the drugs are often prescribed with each other in certain patients for short periods of time. It is important to note that The Beers Criteria for Potentially Inappropriate Medication Use in Older Adults recommends that this drug combination be avoided in older adults.
If coadministration cannot be avoided, provide gastrointestinal protection such as acid reducers. Overall, although a interaction is possible, these drugs may be used together for short periods of time.
Side effects from NSAIDs like ibuprofen, such stomach upset, nausea, heartburn or risk of GI bleeding, may get worse if you take them with steroids like prednisone, especially if taken together for prolonged periods of time. He has been featured in numerous publications including the Huffington Post as well as a variety of health and pharmacy-related blogs.
Please feel free to reach out to him directly if you have any inquiries or want to connect! He's answered thousands of medication and pharmacy-related questions and he's ready to answer yours! Questions Articles Drugs Ask a pharmacist. Published: Jul 13, Last Updated: Oct 27, Taking Indomethacin With Prednisone In our latest question and answer, the pharmacist discusses whether or not it is safe to take indomethacin with prednisone.
Answered By: Dr. Brian Staiger Pharm. Jul 12, Was this article helpful? We'll never share your email with anyone else. Submit Close. Related Questions. Is it ok to take a Zyrtec-D and a Zyrtec in the same day? I am still having some major problems with Allergies.
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Yes, there is a potential interaction between prednisone, a corticosteroid, and indomethacin. However, the drugs are often prescribed with each. Oral prednisolone is as effective as indomethacin for relieving pain in acute gout and should be considered a first-line treatment option. WebMD provides information about interactions between Prednisone Intensol and antipsychotics-sibutramine. Oral prednisolone, etoricoxib, and indomethacin were similarly effective in improving pain, tenderness, and joint activity over 4 days. For. NSAIDs/Corticosteroids Interactions. This information is generalized and not intended as specific medical advice. Consult your healthcare professional. This included abdominal pain, dizziness, and lethargy among patients taking indomethacin and mild hyperkalemia in the patient taking prednisolone. All the patients received 1 g oral paracetamol to be taken every 6 hours as needed. Available in capsules, long-acting capsules, suppositories, and as a suspension. Is there an interaction between metronidazole and acidophilus?Oral prednisolone is as effective as indomethacin for relieving pain in acute gout and should be considered a first-line treatment option, according to a report published online Feb. Colchicine and nonsteroidal anti-inflammatory drugs have been considered the first-line treatment for acute gout for many years. Timothy Hudson Rainer of the emergency medicine academic unit, Cardiff Wales University, and his associates.
They performed a double-blind, randomized trial comparing oral indomethacin against oral prednisolone in patients who presented during a 2-year period to the emergency departments of four Hong Kong hospitals, where acute gout typically is treated in the ED.
Those who were randomized to indomethacin initially received 50 mg two mg tablets of the drug three times a day and six tablets of oral placebo prednisolone once a day for 2 days, followed by 25 mg of indomethacin three times a day and six tablets of placebo prednisolone once a day for 3 days. Prednisolone-treated patients initially received 30 mg three mg tablets of the drug once a day and two tablets of placebo indomethacin three times a day for 2 days, followed by 30 mg three mg tablets of prednisolone once a day and one tablet of placebo indomethacin three times a day for 3 days.
All the patients received 1 g oral paracetamol to be taken every 6 hours as needed. The patients were followed for 2 weeks. Scores on several measures of joint pain, redness, and tenderness were equivalent between the two treatment groups throughout the study period.
During a 2-hour period at the emergency department, mm visual analog scale VAS pain scores at rest declined by 6. VAS scores declined during days of treatment by similar mean amounts both at rest 1. All VAS pain score improvements except for the one at rest in the ED exceeded 13 mm, meeting the definition for clinically meaningful improvement. The number of patients who showed clinically meaningful declines in pain scores also was equivalent between the two groups in both the intention-to-treat and the per-protocol analyses, the investigators said Ann Intern Med.
Both groups also showed similar responses in secondary endpoints of improvement in redness and tenderness of the affected joints, need for additional paracetamol, and patient satisfaction with analgesia. There were no serious adverse events, but seven patients in the indomethacin group and one in the prednisolone group discontinued treatment because of adverse signs or symptoms.
This included abdominal pain, dizziness, and lethargy among patients taking indomethacin and mild hyperkalemia in the patient taking prednisolone. Rainer and his associates noted. Rainer and his associates reported having no relevant financial disclosures. Skip to main content. Prednisolone, indomethacin similarly effective for acute gout.
By Mary Ann Moon. Next Article: FDA approves lesinurad for uric acid lowering in gout.
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